Effects of Levodopa on Regional Cerebral Metabolism and Blood Flow
Identifieur interne : 000A72 ( Main/Exploration ); précédent : 000A71; suivant : 000A73Effects of Levodopa on Regional Cerebral Metabolism and Blood Flow
Auteurs : Ji Hyun Ko [États-Unis, Canada] ; Renata P. Lerner [États-Unis] ; David Eidelberg [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2014.
Abstract
Levodopa has been at the forefront of antiparkinsonian therapy for a half century. Recent advances in functional brain imaging have contributed substantially to the understanding of the effects of levodopa and other dopaminergic treatment on the activity of abnormal motor and cognitive brain circuits in Parkinson’s disease patients. Progress has also been made in understanding the functional pathology of dyskinesias, a common side effect of levodopa treatment, at both regional and network levels. Here, we review these studies, focusing mainly on the new mechanistic insights provided by metabolic brain imaging and network analysis.
Url:
DOI: 10.1002/mds.26041
PubMed: 25296957
PubMed Central: 4314428
Affiliations:
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Lerner</name><affiliation wicri:level="1"><nlm:aff id="A1">Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY</wicri:regionArea><wicri:noRegion>NY</wicri:noRegion></affiliation></author><author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name><affiliation wicri:level="1"><nlm:aff id="A1">Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY</wicri:regionArea><wicri:noRegion>NY</wicri:noRegion></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Levodopa has been at the forefront of antiparkinsonian therapy for a half century. 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Lerner</name></country><country name="Canada"><region name="Manitoba"><name sortKey="Ko, Ji Hyun" sort="Ko, Ji Hyun" uniqKey="Ko J" first="Ji Hyun" last="Ko">Ji Hyun Ko</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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